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Industry 5.0—The Relevance and Implications of Bionics and Synthetic Biology Artical
Peter Sachsenmeier
Engineering 2016, Volume 2, Issue 2, Pages 225-229 doi: 10.1016/J.ENG.2016.02.015
Bionics (the imitation or abstraction of the “inventions of nature) and, to an even greater extent, synthetic biology, will be as relevant to engineering development and industry as the silicon chip was over the last 50 years. Chemical industries already use so-called “white biotechnology” for new processes, new raw materials, and more sustainable use of resources. Synthetic biology is also used for the development of second-generation biofuels and for harvesting the sun´s energy with the help of tailor-made microorganisms or biometrically designed catalysts. The market potential for bionics in medicine, engineering processes, and DNA storage is huge. “Moonshot” projects are already aggressively focusing on diseases and new materials, and a US-led competition is currently underway with the aim of creating a thousand new molecules. This article describes a timeline that starts with current projects and then moves on to code engineering projects and their implications, artificial DNA, signaling molecules, and biological circuitry. Beyond these projects, one of the next frontiers in bionics is the design of synthetic metabolisms that include artificial food chains and foods, and the bioengineering of raw materials; all of which will lead to new insights into biological principles. Bioengineering will be an innovation motor just as digitalization is today. This article discusses pertinent examples of bioengineering, particularly the use of alternative carbon-based biofuels and the techniques and perils of cell modification. Big data, analytics, and massive storage are important factors in this next frontier. Although synthetic biology will be as pervasive and transformative in the next 50 years as digitization and the Internet are today, its applications and impacts are still in nascent stages. This article provides a general taxonomy in which the development of bioengineering is classified in five stages (DNA analysis, bio-circuits, minimal genomes, protocells, xenobiology) from the familiar to the unknown, with implications for safety and security, industrial development, and the development of bioengineering and biotechnology as an interdisciplinary field. Ethical issues and the importance of a public debate about the consequences of bionics and synthetic biology are discussed.
Keywords: Synthetic biology Bio-engineering Biological sensors Biofuels Bio weapons Virtual evolution Protocells Xenocells Economic significance Industry 5.0 Germany China
Porcine pluripotent stem cells: progress, challenges and prospects
Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 8-27 doi: 10.15302/J-FASE-2018233
Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.
Keywords: embryonic germ cells embryonic stem cells induced pluripotent stem cells pigs pluripotent stem cells
Determination of telomerase activity in stem cells and non-stem cells of breast cancer
LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 294-298 doi: 10.1007/s11684-007-0056-9
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8
Keywords: influenza innate T cells CD4+ and CD8+ T cells vaccination
Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review
Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 28-32 doi: 10.15302/J-FASE-2018222
Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.
Keywords: pig pluripotent stem cells primordial germ cells reprogramming
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 20-25 doi: 10.1007/s11684-009-0006-9
Keywords: 4-1BB ligand tumor immunotherapy tumor microenvironment
The past, present and future of bovine pluripotent stem cells: a brief overview
Xiuchun TIAN
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 3-7 doi: 10.15302/J-FASE-2018247
Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveWith the rapid advances in genome-editing and cloning using homologously recombined somatic cells, theneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells
Keywords: bovine embryonic induced pluripotent stem cells
Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue
Jian Jiao, Na Meng, Hong Wang, Luo Zhang
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 486-491 doi: 10.1007/s11684-013-0287-x
Keywords: ciliated cells ciliary beat frequency dissociated tissue culture explant culture nasal epithelial cells
Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 345-353 doi: 10.1007/s11684-013-0282-2
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cellsculture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cellsMoreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown inMorphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture
Keywords: umbilical cord mesenchymal stem cells sweat gland preclinical
Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG
Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6, Pages 1084-1095 doi: 10.1007/s11783-015-0805-y
Keywords: biocathode microbial electrolysis cell microbial fuel cell Cu(II) removal Co(II) removal
Highlights for special issue on “Large Animal Stem Cells”
Jianyong HAN
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 1-2 doi: 10.15302/J-FASE-2019251
Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 41-47 doi: 10.1007/s11684-012-0175-9
Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.
Keywords: umbilical cord mesenchymal stem cells cutaneous regeneration
Xuefu Wang, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x
γδ T cells display unique developmental, distributional, and functional patterns and canγδ T cells are enriched in the liver and exhibit liver-specific features.In this study, we review the properties of hepatic γδ T cells and summarize the roles ofγδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in liver diseases
Keywords: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis
Relationship between Th17 cells and allograft rejection
Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 491-494 doi: 10.1007/s11684-009-0066-x
Keywords: TH17 cells regulation allograft rejection
Frontiers in Energy doi: 10.1007/s11708-023-0901-9
Keywords: interconnector coating plasma spray electrochemical performance Cr diffusion inhibition solid oxide cells
Title Author Date Type Operation
Industry 5.0—The Relevance and Implications of Bionics and Synthetic Biology
Peter Sachsenmeier
Journal Article
Porcine pluripotent stem cells: progress, challenges and prospects
Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU
Journal Article
Determination of telomerase activity in stem cells and non-stem cells of breast cancer
LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao
Journal Article
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Journal Article
Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review
Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA
Journal Article
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
Journal Article
The past, present and future of bovine pluripotent stem cells: a brief overview
Xiuchun TIAN
Journal Article
Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue
Jian Jiao, Na Meng, Hong Wang, Luo Zhang
Journal Article
Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study
Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu
Journal Article
Microbial electrolysis cells with biocathodes and driven by microbial fuel cells for simultaneous enhanced
Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG
Journal Article
Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration
Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu
Journal Article
Relationship between Th17 cells and allograft rejection
Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,
Journal Article